Disclosure: We may earn a commission if you buy through our links. This never affects our editorial independence. Read our disclosure policy.
Expert-reviewed comparison of the best online weight loss programs for 2026. Compare GLP-1 telehealth providers — compounded semaglutide and tirzepatide — with transparent pricing and clinician oversight.
Health & Wellness Editor
GLP-1 medications (semaglutide and tirzepatide) have transformed medically supervised weight loss. Available through telehealth without clinic visits, these programs offer compounded versions at a fraction of the brand-name price with licensed physician oversight. Our team evaluated providers on pricing transparency, medication sourcing, clinician quality, and support.
TrimRx leads the market with 350,000+ happy patients, a 4.9 Excellent Rating, and GLP-1 programs starting at $149/month with $140 off all plans for a limited time. Their compounded semaglutide and tirzepatide programs are available with 0% interest financing.
Shed provides continuous coaching alongside name-brand and compounded GLP-1 options — not just a prescription. Their 2-minute approval assessment and combined coaching model make it the best choice for patients who want guidance beyond the medication itself.
| Feature | TrimRx Weight Loss | Fridays Weight Loss | Yucca Health Weight Loss | Embody Weight Loss | Enhance MD Weight Loss |
|---|---|---|---|---|---|
| Rating | 4.9 | 4.8 | 4.7 | 4.6 | 4.5 |
| Best For | Anyone seeking a proven GLP-1 weight loss program with the largest patient base | Patients wanting compounded tirzepatide or semaglutide with personalized care and no membership fees | Budget-conscious patients seeking the best per-month semaglutide pricing with flexible payment | Patients seeking the lowest-cost entry into physician-supervised GLP-1 weight loss | Cost-conscious patients wanting semaglutide or tirzepatide at the lowest first-month price |
| Key Feature | 350,000+ patients, 4.9 rating, $140 off, 0% financing | Tirzepatide & semaglutide, no membership fees, large promo discounts | $146/month semaglutide, best 6-month per-month rate, 0% financing | GLP-1 from $99/month, 1–2 day delivery, online approval | Same price at every dose, semaglutide from $49 first month |
| Starting Price | Starting at $149/month ($140 off) | Starting at $117/month | $146/mo · 6-month plan $875 | Starting at $99/month | Semaglutide $49/first month, Tirzepatide $99/first month |
| Pros | 5 pros | 5 pros | 5 pros | 5 pros | 5 pros |
| Cons | 2 cons | 2 cons | 2 cons | 2 cons | 2 cons |
| Visit Site | Visit Site | Visit Site | Visit Site | Visit Site |
Our editorial team conducted hands-on testing using a standardized methodology developed over years of product evaluation. Each product was assessed across multiple real-world scenarios before recommendations were finalized.
Read our full testing methodology →ExpertPicked is editorially independent. Advertisers never influence our rankings or recommendations. Every review is produced by credentialed experts with hands-on experience in their respective fields.
Reviewed by
Dr. Lisa ChenHealth & Wellness Editor
Dr. Lisa Chen holds a Doctor of Pharmacy (PharmD) from UCSF and has 8 years of clinical experience in patient care and health education. She specializes in reviewing digital health platforms, wellness products, and nutrition services. Dr. Chen consults with a panel of MDs and registered dietitians to ensure all health content meets clinical accuracy standards.
By Dr. Lisa Chen · 9 min read
By Dr. Lisa Chen · 9 min read
By Dr. Lisa Chen · 9 min read